Paradigm shift: Chinese scientists transform "dispensable" spleen into universal regenerative hub
Peer-Reviewed Publication
Updates every hour. Last Updated: 20-Jun-2025 21:10 ET (21-Jun-2025 01:10 GMT/UTC)
NANJING, China – In a revolutionary one-two punch, Chinese research teams have successfully engineered the human spleen into a living bioreactor capable of curing diabetes and growing functional organs – achievements published back-to-back in Science Translational Medicine and Diabetes this month. This convergence of discoveries positions the long-underestimated spleen as a game-changing platform for regenerative medicine.
The Cuyahoga County Healthcare Sector Partnership, in collaboration with Cleveland Clinic and University Hospitals, is launching the Nursing Clinical Adjunct Faculty Initiative — an innovative program aimed at expanding the region’s nursing education capacity and addressing the national nursing educator shortage.
In a study published in EMBO Molecular Medicine, researchers created a model of XMEA, a rare inherited disease, and show that their mutant zebrafish have weakened muscles and other symptoms that mirror human XMEA disease. This simple model was used to test 30 clinically tested drugs and identify two that significantly improved XMEA symptoms in the zebrafish. The researchers are now studying the VMA21 mutation in a mammalian model, the mouse, to further push research toward a possible clinical treatment.