Self-propelled protein-based nanomotors for enhanced cancer therapy by inducing ferroptosis
Peer-Reviewed Publication
Updates every hour. Last Updated: 20-Jun-2025 00:10 ET (20-Jun-2025 04:10 GMT/UTC)
The development of ferroptosis-based nanotherapeutics is generally limited by poor penetration depth into tumors and potential systemic toxicity.
In a recent issue of International Journal of Extreme Manufacturing, Tu and coworkers from Southern Medical University addressed these challenges by proposing the design and fabrication of self-propelled ferroptosis nanoinducers, composed of only two endogenous proteins with natural bioactivity.
This work offers a strategy for constructing a biocompatible cancer treatment paradigm with enhanced diffusion to achieve deeper penetration into tumor tissues, centered around the concept of ferroptosis.
Organoids, lab-grown 3D miniatures derived from patient tumors, are shedding new light on why some esophageal cancers resist chemotherapy. Researchers at Institute of Science Tokyo (Science Tokyo) used these organoids to pinpoint the molecular drivers of resistance and identified fedratinib as a potential drug. Their findings offer fresh hope for patients with esophageal squamous cell carcinoma, one of the deadliest forms of cancer, by paving the way for more effective, personalized therapies.
A new study to be presented at the SLEEP 2025 annual meeting found that bedtime procrastination in young adults is associated with specific personality traits, including depressive tendencies.
Because of their desirable properties and low cost, plastics are now found everywhere. Their use has become particularly common in agricultural and food production systems since the 1950s. Against this backdrop, the French Ministry of Agriculture and Food Sovereignty; the French Ministry for the Ecological Transition, Biodiversity, Forests, Marine Affairs and Fisheries; and the French Agency for Ecological Transition (ADEME) asked INRAE and CNRS to conduct a collective scientific assessment focused on the use of plastics in agriculture and food production. The assessment synthesised existing knowledge about plastic uses, properties, and recycling. It also examined the impacts of plastics on human health and the environment. These results were presented at a public conference on May 23.
Current data indicate that 20% of plastic usage in France occurs in the context of agriculture and food production, namely for food packaging. The composition and structure of plastics have grown more complex over time, notably as additives and multiple layers have been employed to achieve specific combinations of properties. The result is plastics that are more difficult to recycle. The collective scientific assessment also underscores the massive degree of microplastic contamination—microplastics are found in all the world’s soils and are particularly abundant in agricultural soils. The latter likely contain more tons of microplastics than do the world’s oceans. Additionally, the bodies of all living organisms, including those of humans, are contaminated by microplastics, a reality with adverse health effects. Finally, the assessment highlights that we need research to boost the adoption of plastic alternatives, simplify plastic composition and structure, and better analyse the needs of agricultural and food industry stakeholders as a means for reducing plastic production.
Researchers at Tel Aviv University’s Gray Faculty of Medical & Health Sciences conducted a series of experiments using advanced technologies, focusing on the tumor microenvironment in advanced stages of breast cancer. They found that immune system cells called neutrophils are recruited by the tumor environment and support tumor progression in the later stages of the disease. The researchers stated: "In light of our findings, we believe that neutrophils, which are unique to the tumor environment, may serve as targets for the development of new drugs and as biomarkers for advanced-stage breast cancer."