Excessive bite force does not cause alveolar bone loss but significantly worsens it when combined with periodontitis, report researchers in a new study. While traumatic occlusion has long been suspected to exacerbate periodontitis, the molecular mechanisms behind this link were poorly understood. Now, using mouse models of both conditions separately and combined, the researchers conducted comprehensive gene expression analysis across multiple periodontal tissues, identifying key inflammatory pathways upregulated in bone when both conditions were present.

Metabolic dysfunction‐associated steatotic liver disease (MASLD) and intrapancreatic fat deposition (IPFD) are disorders associated with dysfunctional lipid metabolism and obesity.  In a recent study, researchers have reviewed and compared the definition, causes, diagnostic methods, and emerging treatments of MASLD and IPFD that could help improve patients’ outcomes. In addition, they shed light on recent advances in artificial intelligence applications and presented personalized therapy integrated with the liver‐pancreas axis, providing novel insights for disease management.