Microplastics (MPs) and freshwater acidification jointly threaten aquatic ecosystems. This 21-day study on Eriocheir sinensis revealed synergistic toxicity: combined low pH (6.5) and MPs exacerbated oxidative stress and immune suppression, disrupted the TCA cycle and arginine biosynthesis, and altered gut microbiota function. While MPs alone affected pyrimidine metabolism, acidification amplified MPs' toxicity via immune-metabolic crosstalk. The findings underscore the need to evaluate multiple stressors under climate change, providing critical insights for aquatic risk assessment.

On May 22-23, a select group of scientists from around the world gathered in the small town of Acciaroli in the Cilento-Salerno region of Italy to review a decade’s worth of research in the ongoing Cilento Initiative on Aging Outcomes (CIAO), a longitudinal study of local residents 100 years and older.