PD-1 + IL-2 power couple: Wake up 'sleepy' T cells to turbo-charge cancer cures
Peer-Reviewed Publication
Updates every hour. Last Updated: 22-Sep-2025 23:11 ET (23-Sep-2025 03:11 GMT/UTC)
A landmark mini-review from Peking Union Medical College Hospital delivers a snapshot of nine PD-1/IL-2 bi-functional drugs now in clinical trials. By silencing PD-1 and selectively fueling T cells with refined IL-2 in one molecule, these agents reinvigorate exhausted immune soldiers while sparing healthy tissue, promising safer and broader cancer cures.
Cancer Research UK-funded researchers find dementia-like behaviour in pancreas cells at risk of turning into cancer. The researchers noticed excess “problem protein” molecules forming clumps in these cells, a common feature seen in neurological disease. While early stage, the findings give clues for new ways to study, treat, or potentially prevent pancreatic cancer, a particularly deadly cancer type.
A striking photograph of two male saiga antelope sparring on the banks of a steppe lake is the winner of the 2025 BMC Ecology and Evolution and BMC Zoology image competition.
The discovery of yet another unique animal species from Rēkohu Chatham Islands illustrates how the physical qualities of an animal are influenced by its surroundings.
The next time you breathe, consider this: photosynthesis of algae, powered by iron dust in the ocean, made it possible. Now, a new Rutgers University study published in the Proceedings of the National Academy of Sciences pulls back the curtain on this vital process.
Iron is a critical micronutrient for marine phytoplankton, the microscopic algae that form the foundation of the ocean’s food webs. It is deposited into the world’s oceans as dust from deserts and arid areas as well as from glacial meltwater.