Synthetic engineering of telomerase RNA, development of polygenic scores paves way to better understanding of telomeres
Peer-Reviewed Publication
Updates every hour. Last Updated: 23-Sep-2025 01:11 ET (23-Sep-2025 05:11 GMT/UTC)
The critical role that telomeres play in aging and age-related disease has long made them a target of research. Recent work at Boston Children's Hospital to engineer synthetic telomerase RNA to increase telomere length and develop polygenic scores to unravel the genetic underpinnings of telomere biology disorders is expanding our understanding.
A new technology, presented by University at Buffalo scientists in a study published in Nature Communications, centers on a pig enzyme called ST3Gal1. Researchers retrained it to bind to glycans instead of building them. This new glycan-binding enzyme, which scientists named sCore2, could help analyze and treat diseases via sugar patterns found on the surface of cells.
In a new study published in Current Biology, an international team of researchers discover the first evidence of an XX/XY sex determination system in chambered nautiluses and challenge the previously believed system of ZZ/Z0.
SAN FRANCISCO, CA — Today, PLOS Biology announced a new agreement with the Research on Research Institute (RoRI) and the Association for Interdisciplinary Meta-Research and Open Science (AIMOS) to become a partner journal with MetaROR (MetaResearch Open Review), a recently launched platform designed to improve the dissemination and evaluation of meta-research. As part of the agreement, PLOS Biology will formally consider meta-research articles that are peer-reviewed on the MetaROR platform, collaborating with RoRI and AIMOS to improve the transparency of peer review in the field of meta-research.
Hypertensive disorders in pregnancy (HDPs), marked by high blood pressure, may influence fetal and placental growth differently by sex. To investigate this, researchers in the United States analyzed birth data and found that male babies of mothers with HDPs had higher birthweight, while female babies had relatively heavier placentas. These findings highlight sex-specific responses to HDPs and may help guide more personalized strategies for monitoring and managing pregnancy and fetal health outcomes.