Researchers develop an interpretable hybrid feature selection model to overcome the "curse of dimensionality"in genomic selection, pinpointing key genetic markers for global food security.

Dr Ainara Ballesteros is a Juan de la Cierva postdoctoral researcher at the Institute of Environment and Marine Science Research at the Catholic University of Valencia, where she leads a research group focused on jellyfish biology, aquaculture, and the sustainable use of marine resources. Her work is centered on developing innovative solutions based on marine science, particularly through the study of underused organisms as sources of high-value compounds within circular bioeconomy and zero-waste strategies.

She is joined in this work by Raquel Torres, a PhD student at the same institute, who is carrying out her doctoral thesis within this line of research, focused on jellyfish valorization, collaboration with the fishing sector, and the sustainable management of marine resources.

They are co-authors on a new Frontiers in Marine Science article which investigated whether jellyfish accidentally caught by small-scale fishers in Spain could be transformed into a valuable resource instead of being treated as waste. The team worked side by side with fishers to better understand their perceptions of jellyfish bycatch, identify which species are most frequently caught, and evaluate whether one of them, Rhizostoma pulmo, could serve as a sustainable source of high-quality collagen.

Alterations in the bacterial composition in various anatomical sites of the human body have been associated with tumorigenesis and the progression of multiple cancers; however, divergent results regarding enriched bacteria have been reported across studies of the same disease, indicating cohort-dependent bacterial compositional variance. To move beyond this inconsistency, a research team led by Professor Na Liu from Sun Yat-sen University Cancer Center proposes a fundamental shift in perspective. The team argues that it is the functional repertoire of bacterial communities, rather than their taxonomic identity, that serves as the core driver of tumor progression. The team proposes the unified nomenclature of bacterial functional constituents as “tumor-associated bacterial effectors” (TABEs), categorizing them into six functional classes according to their chemical nature, conserved structural features, and analogous mechanisms of action in regulating host cells. The researchers believe that exploring the mechanisms of TABEs in cancer represents a critical step toward harnessing their biological potential in real-life clinical settings.

Confronting the central challenge of how necroptosis reconciles high sensitivity to stimuli with robustness against intrinsic noise in complex living systems, this study systematically dissect the underlying design principles that govern cell-fate decisions. By integrating biophysical modelling with large-scale topological screening, we resolve the intricate biochemical reaction network into a minimal set of organizing rules. Our analysis identifies the incoherent feedforward loop (IFFL) as the core functional motif driving the observed dynamics. This topology endows the system with a distinctive bell-shaped input–output response, scale invariance, and the capacity to switch precisely between apoptotic and necrotic fates. Beyond elucidating the dynamical logic of cell death signalling, this work reveals, from a physics-informed perspective, a unifying “complexity-to-simplicity” design principle that may underlie the evolutionary construction of sophisticated signalling networks. It further provides a conceptual framework for understanding how dysregulation of cell-fate decisions contributes to pathological processes such as inflammation and tumorigenesis.

Liver organoids, three-dimensional structures derived from stem cells or hepatic progenitors, have emerged as a transformative technology. Unlike traditional two-dimensional cultures or animal models, organoids faithfully recapitulate the complex architecture and functionality of native liver tissue. This review summarizes recent advancements in liver organoid technology, detailing their development, classification, and key applications.