In the past several decades, significant progress has been made in controlling molecular chirality, as evidenced by the several Nobel Prizes in chemistry awarded in this area, particularly for advancements in the asymmetric catalytic synthesis of molecules with central and axial chirality. However, the exploration of new types of chirality has been largely stagnant for more than half a century, likely due to the complexity and challenges inherent in this field. Prof Li and Liang’s groups at Texas Tech University present the discovery of a novel type of chirality—staircase chirality.

https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/15/issue/3

Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.

A Northwestern University-led international team of scientists has, for the first time, directly observed catalysis in-action at the atomic level. In mesmerizing new videos, single atoms move and shake during a chemical reaction that removes hydrogen atoms from an alcohol molecule. By viewing the process in real time, the researchers discovered several short-lived intermediate molecules involved in the reaction as well as a previously hidden reaction pathway.