Targeting SUMOylation in glioblastoma opens new avenue for therapeutic interventions and biomarker discovery

Lung adenocarcinoma (LUAD) remains one of the world’s most fatal cancers, driven by complex genetic and epigenetic alterations that shape tumor behavior. Previous work revealed that the TBX2 transcription factor subfamily—Tbx2, Tbx3, Tbx4, and Tbx5—is frequently down-regulated in LUAD, yet whether this suppression actively contributes to tumorigenesis or merely reflects downstream transcriptional reprogramming has remained unclear.

Researchers at the Korea Institute of Energy Research (KIER), led by Dr. Hookyung Lee, have developed an electrified heat treatment technology that replaces fossil fuels with electricity in the metal heat treatment process used in galvanized steel-strip production for automobiles and household appliances. The technology is expected to be broadly applicable across energy-intensive industries such as steelmaking, supporting decarbonization of industrial processes.

Pancreatic metastases are rare and frequently misdiagnosed, leaving clinicians uncertain about how to assess prognosis and select optimal treatment. In a recent large single-center retrospective study, researchers analyzed 77 cases of pancreatic metastases over a 10-year period. They found that survival varied substantially depending on the primary tumor type and whether metastases occurred synchronously (diagnosed alongside the primary cancer) or metachronously (developing months or years after primary tumor treatment). Metastases from clear cell renal carcinoma (CCRC) were the most common and were associated with the most favorable outcomes, particularly when radical surgical resection was performed. The findings provide real-world evidence to guide diagnosis, prognostic assessment, and treatment decisions for this uncommon but clinically challenging condition.

Harnessing solar energy to enhance the rechargeable zinc–air batteries (RZABs) performance is a promising avenue toward sustainable energy storage and conversion. Simultaneously enhancing light-absorption capacity and carrier separation efficiency in nanomaterials, as well as improving electrical conductivity and configuration for electrocatalysis, presents a formidable challenge due to inherent trade-offs and interdependencies. Here, we have developed a Janus dual-atom catalyst (JDAC) with bifunctional centers for efficient charge separation and electrocatalytic performance through a bipolar doping strategy. The in situ X-ray absorption near-edge structure and Raman spectroscopy analyses demonstrated that the Ni and Fe centers in JDAC not only function as effective sites for oxygen evolution reaction and oxygen reduction reaction, respectively, but also serve as efficient hole and electron enrichment sites, effectively suppressing photoelectron recombination while enhancing photocurrent generation. As a result, the assembled JDAC-based light-assisted RZABs exhibited extraordinary stability at large current densities. This work delivers pivotal insight to design Janus dual-atom catalysts that efficiently convert solar energy into electric and chemical energy.

Recently, micro/nanosatellites have become a significant trend in space with the rapid development of space technology, microelectromechanical systems, and commercial off-the-shelf components. However, most traditional micro/nanosatellites have poor reliability and real-time performance. The implementation of a real-time operating system (RTOS) can effectively prevent system crashes due to untimely responses, thereby enhancing the real-time performance and reliability of the micro/nanosatellite attitude determination system. The Dalian-1 Lianli satellite, a 17-kg 12U high-resolution remote sensing CubeSat, was developed to validate a series of innovative technologies, including submeter high-resolution remote sensing imaging, the high-reliability OpenHarmony real-time operating system (RTOS), and the nontoxic hydroxylamine nitrate propulsion system. The satellite first uses the free, high-reliability OpenHarmony RTOS in the world. Launched on 2023 May 10, aboard the Tianzhou-VI cargo spacecraft, the satellite was successfully deployed into orbit on 2024 January 18, following 253 d of in-orbit storage at the China Space Station.

This study systematically elucidates the drug resistance mechanisms of five highly pathogenic viruses, proposes five innovative anti-resistance strategies, and integrates artificial intelligence technology to establish a next-generation antiviral drug research and development framework, thereby providing critical theoretical support and transformative pathways for addressing clinical challenges associated with drug resistance.

Researchers have developed an easy-to-apply antibacterial hydrogel by incorporating a biodegradable oligomer into a thermosensitive matrix. This hydrogel kills drug-resistant bacteria through a triple-action mechanism and demonstrates effective wound protection in biological models.