12-Nov-2025 Knowledge mining inspired therapy of osteoporosis by magnetic hydrogel mediated precise stimulation of vagus nerve under a rotational magnetic field Tsinghua University Press Significant relationship between vagus nerve and bone remodeling was identified through artificial intelligence (AI)-based knowledge mining. Iron oxide nanoparticles incorporated injectable hydrogels (termed M-Gels) were applied to rats' left neck vagus nerves, showing at least 20-week retention. Magnetic vagus nerve stimulation (mVNS) at 20 Hz twice daily for 16 weeks enhanced bone metabolism. AI analysis identified gut microbiota as a contributing factor, highlighting mVNS's potential for osteoporosis treatment. Journal Nano Research
12-Nov-2025 Simultaneously supplementing Wtp53 and degrading Mutp53 using a virus-mimicking mRNA delivery system to restore P53's autonomous anti-cancer function Tsinghua University Press Restoring P53's autonomous anti-cancer function through P53 mRNA delivery is a promising anti-tumor strategy. Yet, in tumors harboring mutant P53, the existing mutant P53 (Mutp53) would interferes with the anti-tumor function of Wtp53 through dominant-negative effect. Herein, we designed Vir-Z@R, a P53-repair nano-system based on a virus-mimicking nanostructure to deliver P53 mRNA and Zn (II) into tumor cells. By supplementing Wtp53 through P53 mRNA delivery and promoting the degradation of mutant P53 via a zinc ion-mediated proteasomal pathway, Vir-Z@R restore the autonomous tumor-suppressive function of P53 and induce tumor cell death through multiple mechanisms (interfering with energy metabolism and inducing apoptosis), leading to delayed tumor growth and prolonged survival in mice with Mutp53. This study provides a strategy for treatment of P53-mutant tumor. Journal Nano Research
12-Nov-2025 Sound waves tapped to unleash hidden power of 2D materials for revolutionary electronics & brain chips Tsinghua University Press Scientists have harnessed sound waves to break a fundamental barrier in next-gen electronics. By using surface acoustic waves instead of traditional electricity to control 2D materials, they can now distinctly identify whether electrical current is carried by electrons or hole. This breakthrough unlocks a new dimension for designing ultra-high-density memory and brain-inspired neuromorphic chips with significantly more data states and tunable synaptic weights, enabling smarter, more compact devices. Journal Nano Research
12-Nov-2025 XAFS reveals the potential of single-atom catalysts: progress, challenges, and future Tsinghua University Press With the growing demand for more efficient and sustainable chemical processes, single-atom catalysts (SACs) have become a research hotspot due to their high atomic utilization and unique catalytic performance. As a core characterization tool, XAFS (X-ray absorption fine structure) technology can deeply study the microscopic chemical environment of SACs, providing key data for catalyst design. This article is based on a review published in Nano Research, exploring the progress, challenges, and future prospects of XAFS in SACs research, aiming to provide readers with comprehensive scientific insights. Journal Nano Research
12-Nov-2025 How sweet alyssum turned purple: scientists trace the domestication of flower color Nanjing Agricultural University The Academy of Science Flower color in ornamental plants not only enhances their aesthetic appeal but also reflects complex evolutionary histories. Journal Horticulture Research
11-Nov-2025 Enhancing the reliability of machine learning for gravitational wave parameter estimation with attention-based models Osaka Metropolitan University Osaka Metropolitan University researchers developed a technique to improve machine learning reliability and estimation results of gravitational wave parameters. Journal Physical Review D
11-Nov-2025 Global footprint of wildlife trade highlights biodiversity threats University of Melbourne New research has shed light on the vast and largely unmonitored trade of wildlife around the world, revealing alarming threats to biosecurity and the survival of many species. Journal Current Biology
11-Nov-2025 Treatment with antibiotics and steroids in adults with pneumonia addressed in latest clinical practice guideline American Thoracic Society Pneumonia, a largely preventable disease, caused more than two million deaths in 2021, according to the Global Burden of Disease report. Evidence-based guidance on its diagnosis and management is, therefore, a priority for clinicians. Now, the American Thoracic Society has published a new clinical practice guideline (CPG), which expands upon its 2019 recommendations. Journal American Journal of Respiratory and Critical Care Medicine
11-Nov-2025 Montreal’s electric buses use more energy in winter but are still more cost-effective than diesel Concordia University A Concordia study found that Montreal’s electric buses consume 26% more energy in winter due to colder temperatures, road friction, and the need for interior heating. Despite this seasonal drop in efficiency, they remain 40–60% cheaper to operate than diesel buses and continue to reduce greenhouse gas emissions. Journal Transportation Research Funder Natural Sciences and Engineering Research Council of Canada, Fonds de recherche du Québec
11-Nov-2025 Viewing AI as magical sparks adoption among less tech-savvy consumers American Marketing Association Consumers with lower AI literacy are more likely to adopt AI tools because they view AI as magical and awe-inspiring. Journal Journal of Marketing
