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Updates every hour. Last Updated: 26-Oct-2025 04:11 ET (26-Oct-2025 08:11 GMT/UTC)
Leveraging an electron-acceptor engineering strategy to regulate excitation dynamics of dyes for devising ideal phototherapeutic agents in synergistic photodynamic/mild-photothermal tumor therapy
Chinese Chemical SocietyRecently, the team of Academician Xiaojun Peng from Dalian University of Technology, Associate Professor Haidong Li, and the team of Professor Juyoung Yoon from Ewha Womans University, South Korea cooperated to develop a series of near-infrared (NIR) dyes with aggregation-induced emission (AIE) characteristics, based on an electron-acceptor engineering strategy to regulate the excited-state dynamic processes of dyes. By introducing diphenylamine into the xanthene structural unit, due to the increase in freely rotatable single bonds and asymmetric structures, the dyes exhibited enhanced AIE characteristics as well as potential for photodynamic therapy (PDT), photothermal therapy (PTT), and photoacoustic imaging (PAI). Variation in the number of cyano groups within the dyes could regulate their excitation wavelength, PDT efficacy, and PTT capability. Experimental results showed that Hcy-ON displayed high ROS production and heat-generating capacity under 760 nm laser irradiation. Molecular theoretical calculations indicated that Hcy-ON exhibited a significant spin–orbit coupling matrix element (SOCME) value <S1|SOC|T3>, with the minimum energy gap between S1 and T1 energy levels being 0.678 eV, which is related to its strongest ROS generation capability. In addition, analyses of the singlet–triplet (S–T) energy gap, electron transition mechanism, root-mean-square displacement (RMSD) value, and Huang–Rhys factor confirmed the excellent photothermal performance of Hcy-ON. This strategy provides a new paradigm for constructing multimodal light-driven tumor therapies. This research work was published in CCS Chemistry.
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- CCS Chemistry
Study finds gaps in support service use among older breast cancer patients
Hebrew SeniorLife Hinda and Arthur Marcus Institute for Aging Research- Journal
- Journal of Geriatric Oncology
- Funder
- Virginia Ellicott Simpson Aisner Fund, Suprenant Fund, Jog for Julie Foundation, Bakes for Breast Cancer
Study finds prenatal cannabis exposure delays reproductive development in female offspring
Washington State University- Journal
- Toxicological Sciences
First in situ observation of partial dislocation mediated plastic flow in shocked single-crystal aluminum Fig. 1 a Incident X-ray pulse and loading laser layout for time-resolved XRD. b Shaped flat-top laser profile in experiments. c The modulated spect
Ultrafast Science- Journal
- Ultrafast Science
New imaging techniques show what happens inside your bones during hip replacement surgery
University of Warwick- Funder
- EPSRC
Turning old wind turbine blades into desert sand barriers
KeAi Communications Co., Ltd.- Journal
- International Soil and Water Conservation Research
- Funder
- National Key Research and Development Program of China, Key Research and Development Projects of Ningxia Hui Autonomous Region, Major Science and Technology Projects of Inner Mongolia Autonomous Region “Open Bidding for Selecting the Best Candidates”, Excellent Member of Youth Innovation Promotion Association CAS
KIST researchers overturn existing theory, "Controlling the spread of oil in the subsurface, hydrophilic materials are more effective"
National Research Council of Science & TechnologyDr. Seunghak Lee, Jaeshik Chung, and Sang Hyun Kim of the Water Resources Cycle Research Center at the Korea Institute of Science and Technology (KIST) observed how oil and water interact in porous media under various conditions using a "microfluidic system" that allows precise observation of microscopic fluid flows.
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- npj Clean Water
- Funder
- Ministry of Science and ICT
APSNA position statement urges action on firearm safety
SAGEThe American Pediatric Surgical Nurses Association, Inc. (APSNA) has released a comprehensive position statement declaring firearm violence a public health crisis and outlining actionable steps to prevent firearm-related injuries and deaths among children and teens. Firearms are now the leading cause of death for pediatric patients aged 1–19 in the United States. APSNA calls for a public health approach to prevention, emphasizing the role of nurses in clinical screening, education, research, and advocacy.
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- Journal of Pediatric Surgical Nursing
Ethylene and 1-MCP team up to halt sweet potato sprouting and prolong shelf life
Maximum Academic PressA research team indicates that treatments with ethylene and 1-methylcyclopropene (1-MCP), especially in combination, dramatically inhibit postharvest sprouting, enhance flavor and color, and extend shelf life.
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- Plant Phenomics