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Updates every hour. Last Updated: 3-Nov-2026 01:15 ET (3-Nov-2026 06:15 GMT/UTC)
Applications of large-scale artificial intelligence models in bioinformatics
Higher Education PressHigh-throughput technologies are currently flooding life sciences with massive, highly complex multi-omics and biological imaging datasets. Classical machine learning and deep learning methodologies, while useful, often hit major roadblocks. These include high dependence on high-quality annotated data, weak generalization to unseen datasets, and significant computational bottlenecks when dealing with massive data scales.
- Journal
- Quantitative Biology
A multi-condition diffusion framework enables precise prediction of drug-induced transcriptional changes
Higher Education PressDeciphering how drugs alter cellular gene expression is essential for new drug screening and personalized medical treatment. Scientists mainly rely on high-throughput sequencing to capture drug perturbation transcriptomic profiles, yet this experimental method suffers from high costs and long testing cycles, making it impossible to cover countless combinations of chemical compounds, cell lines and administration dosages.
- Journal
- Quantitative Biology
Occult metastatic non-small cell lung cancer presenting as sepsis with multi-organ dysfunction: a diagnostic challenge, a case report
Higher Education PressA 67-year-old woman with no known chronic illnesses presented with bilateral leg swelling, weakness, and fatigue, rapidly progressing to septic shock, acute kidney injury, and deep vein thrombosis. Chest imaging revealed a pulmonary mass, hepatic lesions, and a brain metastasis. Despite broadspectrum antibiotics, cultures remained negative and her condition worsened. A liver biopsy confirmed metastatic nonsmall cell lung adenocarcinoma. The case underscores that occult malignancy can mimic or coexist with sepsis, and failure to improve within 48–72 hours of antimicrobial therapy should prompt early evaluation for cancer, multidisciplinary involvement, and timely goals-of-care discussions..
- Journal
- Malignancy Spectrum
Head and/or neck cancer deviates the tryptophan, arginine and glutamine pathways: applications in diagnosis and prognosis
Higher Education PressA pilot study from Venezuelan and U.S. institutions reveals significant metabolic reprogramming of tryptophan, arginine, and glutamine pathways in head and neck carcinoma (HNC) patients. Serum tryptophan and the arginine/putrescine ratio emerged as potential dynamic biomarkers for monitoring treatment response, while the glutamine-to-glutamate shift indicates enhanced glutaminolysis in active tumours. The findings provide a rationale for larger validation studies and offer low-cost analytical tools for resource-limited settings.
- Journal
- Malignancy Spectrum
Merging metasurfaces with image sensors for ultra-compact optoelectronics
Higher Education PressA comprehensive review explores the developmental trajectory of integrating metasurfaces with photodetectors, highlighting the transition from traditional bulk optics to fully integrated, single-chip optoelectronic sensing architectures.
- Journal
- Frontiers of Optoelectronics
Reliable chaos-based secure communication realized via programmable optical lattices
Higher Education PressResearchers have developed a programmable synthetic temporal lattice using optical fiber loops to generate and synchronize chaotic light signals, providing a stable method for data transmission.
- Journal
- Frontiers of Optoelectronics
Broadband light synergy offers a promising avenue for neural repair in Acute Parkinson’s disease
Higher Education Press- Journal
- Frontiers of Optoelectronics
NUS CDE researchers merge multiple physiological signals into a single patch for simpler health monitoring
National University of Singapore College of Design and Engineering- Journal
- Nature
Quantum devices: First gate-defined quantum dots realized in zinc oxide
Advanced Institute for Materials Research (AIMR), Tohoku University- Journal
- Nature Communications