The Herpes simplex virus is a widespread virus that often causes cold sores, and most people carry it. By removing a virulence gene, i.e. a gene that makes the virus harmful to humans, the herpes virus can be repurposed as a cancer vaccine. This modification prevents the virus from harming healthy tissue while allowing it to target cancer cells, which function differently from normal cells. These findings are presented in a new doctoral thesis at Åbo Akademi University, Finland.

Aging brain shows deterioration of blood-brain barrier (BBB), but the underlying mechanisms are unclear. Guo et al, from Massachusetts General Hospital, reported that the effects of astrocytes on endothelial cell permeability depend on the “age” of astrocytes, and increased angiotensinogen expression in senescent astrocytes may be one of the mediators. These data suggest the importance of cell-cell interaction in neurovascular unit, and point towards a potential therapeutic approach to rescue BBB in aging brain.

Immune cells called double negative T cells are abundant in the intestine but have been poorly understood till date. In a recent study, researchers from Institute of Science Tokyo report that these cells actually have an indispensable role in suppressing intestinal inflammation. Through cutting-edge microscopy that allows live imaging, the movement and functioning of these cells were visualized for the first time, providing insights into conditions such as Crohn’s disease.

Phospholipids, essential components of cell membranes, are increasingly recognized for their active roles in regulating innate immunity and inflammation. A new review is published to outline how phospholipid metabolism shapes immune cell behavior, influences the outcome of host defense and tissue homeostasis. The authors also discuss how dysregulation of phospholipid metabolism contributes to inflammatory diseases, such as autoimmune diseases, cardiovascular diseases and cancers, and highlight the potential strategies of restoring phospholipid homeostasis for disease treatment.

Two distinct stem cell lineages that drive tooth root and alveolar bone formation have been identified by researchers from Science Tokyo. Using genetically modified mice and lineage-tracing techniques, the team shed light on the cell signaling mechanisms guiding differentiation in stem cells in the developing teeth, offering key insights for future regenerative dental therapies.