Type 2 diabetes (T2D) is a metabolic disorder characterized by insulin resistance (IR), inflammation, and dysregulation in glucose metabolism. The disease is spreading globally, partly due to aging, which can damage the immune system and speed up the progression of the metabolic disorder. This review primarily delves into the triggers for T2D within the framework of the ominous octet, which emphasizes 8 principal factors under the “ominous octet” framework that contribute to high blood glucose and associated metabolic disorders. The article studies the interplay of hyperinsulinemia, mitochondrial dysfunction (MD), and endoplasmic reticulum (ER) stress with immune aging in driving disease progression affecting each component of the octet. MD and ER stress can result in defects in insulin signaling, ultimately leading to β-cell death. Chronic inflammation associated with aging, also known as inflammaging, especially affects older adults by worsening IR and glucose regulation, which creates a continuous sequence of metabolic problems. Thus, the “ominous octet” framework provides fundamental knowledge to develop personalized treatment approaches that target metabolic dysfunction together with ER stress, MD, and immune system imbalances. These strategies show promising potential to improve treatments for T2D and may lead to better health outcomes for older adults dealing with this condition.

Amid a growing youth mental health crisis, a new study shows that hope is a powerful protective force for adolescents. Beyond boosting emotional and physical well-being, higher levels of hope significantly reduced bullying and cyberbullying. Hopeful teens – those who believe in their goals and pathways to achieve them – were more than one third less likely to harm others. Those with less hope were more than 50% more likely to engage in such behavior. For parents, educators and policymakers: hope is a critical tool for prevention.

USF launches what’s believed to be the world’s first university-based undergraduate concentration in health care simulation operations, preparing students for a rapidly growing, high-impact field.

A study led by researchers from the University of Michigan showed that targeting CDK12 and a related gene, CDK13, strongly activates the stimulator of interferon genes, or STING, signaling pathway, enhancing the effectiveness of immunotherapies.

Ocean health 66 million years ago analysed in an international study with the participation of EHU researcher Vicente Gilabert and published in Nature Communications