Organ donation following medical assistance in dying (MAiD), also known as euthanasia, is a relatively new practice both in North America and worldwide. A first comparison of liver transplantation using organs donated after MAiD in Canada has shown good patient survival with outcomes similar to standard donation after circulatory death. The findings from the new study in the Journal of Hepatology, published by Elsevier, highlight that this practice can help to meet the increasing demand for organs by expanding the donor pool, thereby saving more lives.

A recent review article published in Molecular Biomedicine highlights that the clinical development of targeted therapies against the WNT signaling pathway, a key target in cancer treatment, is ushering in new breakthroughs. The review begins with the fundamental mechanisms of Wnt signaling and systematically elaborates on various innovative strategies targeting the WNT pathway, critically assessing their clinical prospects. It emphasizes that by overcoming specificity challenges, developing precise biomarkers, and exploring synergistic effects with therapies such as immunotherapy, targeting the WNT pathway holds the potential to pioneer new paradigms for future precision cancer medicine.

Adelaide researchers have identified a promising new biomarker and treatment target for ovarian cancer that could markedly improve the outlook for women diagnosed with this aggressive disease.