The new technology identifies the tumor's biological fingerprint with more than 90% accuracy and could complement CT scans in monitoring patients' response to treatment.

Chronic hepatitis B is difficult to completely eradicate because current antiviral therapies cannot eliminate viral covalently closed circular DNA. Researchers now summarize how combining classical hepatitis B virus markers with emerging biomarkers, including hepatitis B core-related antigen, serum hepatitis B virus RNA, and quantitative anti-hepatitis B core antibody, substantially improves prediction of functional cure. The proposed evidence-based clinical framework could support individualized treatment decisions, optimize monitoring strategies, improve hepatitis B surface antigen clearance, and reduce healthcare costs.

Eye AI is moving fast, but will it work for people living at high altitude? In a study accepted by Science Bulletin, Dr. Wu Yuan’s team found that leading ophthalmic foundation models can lose accuracy across high-altitude retinal image cohorts. The team developed MIXFound, a lightweight way to combine several models and make AI diagnosis more robust in underrepresented settings.

Type 2 diabetes usually develops over many years, yet preventive measures often begin only once blood glucose levels are already elevated. An international panel of experts led by University Hospital Tübingen and the German Center for Diabetes Research (DZD) is therefore calling for a fundamental shift in thinking: diabetes prevention should take the entire life course into account—from the period before pregnancy through older adulthood. In an article published in the journal Nature Medicine, the researchers present the first jointly developed ten-point framework for preventing type 2 diabetes and its complications. The publication was initiated and led by researchers from University Hospital Tübingen and the DZD. Together with leading experts in basic research, clinical medicine, and diabetes prevention, they reviewed the current evidence and developed concrete recommendations for research, prevention, and healthcare.

For children with early-onset progressive high myopia, the concern is not limited to stronger glasses or longer eyeballs. Over time, high myopia can be associated with structural changes at the back of the eye, including fundus tessellation, choroidal thinning, and myopic maculopathy. These changes may accumulate over many years and increase the risk of future visual impairment. This means that evaluating high myopia interventions should not rely only on refractive error and axial length, but should also consider whether the fundus is undergoing early structural deterioration.  A study published in Eye Discovery provides new evidence from this perspective. Researchers from the Eye & ENT Hospital of Fudan University and the Key Laboratory of Myopia and Related Eye Diseases evaluated three-year changes in refractive status, axial length, and quantitative fundus parameters in children with progressive high myopia who underwent posterior scleral reinforcement (PSR). The procedure used a crosslinked bovine pericardial patch, with the aim of reinforcing the posterior part of the eye and exploring its potential effect on high myopia-related fundus changes.