This review identifies PI3K/AKT/mTOR pathway activation, hypoxia (mediated by HIF-1), and glucose metabolism (glycolysis, PPP, OXPHOS) as core drivers of SCLC radioresistance. Innovatively, it clarifies their crosstalk: PI3K/AKT/mTOR regulates glucose metabolism via HIF-1 and by inhibiting G6PD ubiquitination. Clinically, targeting these axes—with PI3K/mTOR inhibitors, HIF-1 antagonists, or glucose metabolism blockers—may enhance SCLC radiosensitivity, providing actionable strategies to overcome 放疗 resistance in this aggressive cancer.

A research team has developed a novel approach to studying the dissolution mechanisms of waste glasses, a critical process for predicting the long-term release of contaminants like radionuclides from vitrified waste in geological disposal sites.

USC Dornsife scientists found that merging EEG and brain fMRI data can better predict which teens are most likely to develop anxiety as they grow. The researchers followed 176 adolescents, first scanned at age 13 and again at 15, as part of a decades-long study funded by the National Institute of Mental Health. They found that teens who were shy or cautious as babies showed distinct brain activity patterns linked to anxiety risk. Alos, merged images (“EEG–fMRI fusion”) explained about 25% of the differences in anxiety changes — far more than either brain scan alone.

Common jobs held by immigrant women, such as house cleaners and nurses, may expose them to dangerous chemicals that could increase their risk of breast cancer, according to a new study led by Silent Spring. The findings shed light on overlooked risks for female workers and why some groups of immigrants experience higher rates of breast cancer after moving to the United States.

Pediatric guidelines part of global CPR guideline update