N⁶-methyladenosine (m⁶A) is the most abundant internal RNA modification in eukaryotes, regulating RNA splicing, translation, stability, and degradation. This reversible modification is dynamically controlled by three groups of proteins—“writers,” “erasers,” and “readers.” The writers (e.g., METTL3, METTL14, and WTAP) install methyl groups onto RNA, the erasers (such as FTO and ALKBH5) remove them to maintain epigenetic balance, and the readers (YTH and IGF2BP family proteins) interpret these methylation marks to fine-tune gene expression. Together, they form a central regulatory network essential for normal reproductive physiology and fertility.

Liver diseases are a growing global health and economic challenge. High alcohol consumption, aging, and increased exposure to metabolism-related risk factors may contribute to an increase in mortality rates associated with alcohol-related liver disease (ALD) and metabolic-associated fatty liver disease (MAFLD), underscoring the need to understand their pathogenesis to develop better prevention and therapeutic strategies.

A recent randomized controlled pilot study suggests that Baduanjin, a traditional Chinese mind-body exercise, may help alleviate menopausal symptoms and fatigue in breast cancer patients undergoing aromatase inhibitor therapy. The study, published in Translational Exercise Biomedicine (ISSN: 2942-6812), an official partner journal of International Federation of Sports Medicine (FIMS).

Yueju Pill, a classic traditional Chinese medicine, shows antidepressant effects rapidly. However, biomarkers that can predict its treatment outcomes in major depressive disorder (MDD) are still lacking. Multimodal magnetic resonance imaging (MRI) offers a promising avenue to identify such biomarkers. This pilot study aimed to explore whether therapeutic responses to Yueju Pill could be predicted by MRI-derived brain networks and to identify drug-specific biomarkers in comparison to escitalopram, a mainstream antidepressant.

More expensive steak, cheaper tomatoes, but the same total cost for the average basket of groceries at the supermarket. A comprehensive study, led by researchers from Chalmers University of Technology in Sweden has analysed the potential effects of a food tax shift – where VAT is removed from healthy foods and levies are introduced on foods that have a negative impact on the climate. The study shows that a shift in taxes could have both environmental and human health benefits, and means that 700 fewer people in Sweden would die prematurely each year.