CD2AP and Alzheimer’s disease: A key regulator of neurodegeneration and potential therapeutic target
Peer-Reviewed Publication
Updates every hour. Last Updated: 31-May-2025 08:09 ET (31-May-2025 12:09 GMT/UTC)
A comprehensive Thought Leaders Invited Review in Brain Medicine highlights the crucial role of CD2-associated protein (CD2AP) in Alzheimer’s disease (AD). CD2AP influences amyloid-beta processing, tau pathology, synaptic integrity, and neuroinflammation. The review outlines its cell type-specific effects in neurons and microglia, suggesting new therapeutic possibilities. Understanding these mechanisms could lead to innovative treatment strategies for AD.
A new paper in Nicotine & Tobacco Research indicates that different nicotine pouches, which have become very popular in recent years, particularly among young people, may influence user preferences very differently. An investigation using rats finds some flavors lead to much more nicotine consumption than others.
This study identifies immature platelet fraction (IPF) as a moderate predictor for platelet recovery, enhancing our understanding of dengue management. The findings support IPF's clinical utility as an early indicator of recovery, improving patient monitoring and guiding timely interventions.
USC researchers have found that persistent organic pollutants (POPs)—synthetic toxic chemicals often found in food sources and stored in body fat — are associated with long term higher blood pressure in adolescents who have undergone bariatric surgery. The study suggested that POPs diminished the beneficial effect of bariatric surgery on improved blood pressure due to disruptions in lipid metabolism. The study included data from 57 adolescents from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) consortium, who underwent bariatric surgery. Researchers measured the level of POPs stored in adipose tissue before surgery. After they assessed whether it affected blood pressure in the short term—at 6 months, and then five years after surgery. They found that POPs mixtures were linked to higher systolic blood pressure five years after bariatric surgery. The study also identified a plausible biological pathway explaining the relationship between POPs and changes in blood pressure. The researchers’ analysis revealed that one particular pathway involved in the production of prostaglandin was key in influencing blood pressure changes in the long-term. These findings could eventually lead to treatments to reduce adverse health effects of exposure to these environmental chemicals on individuals with obesity, particularly for those pursuing weight-loss interventions such as bariatric surgery.