Highly educated people face steeper mental declines after stroke
Peer-Reviewed Publication
Updates every hour. Last Updated: 9-Aug-2025 12:11 ET (9-Aug-2025 16:11 GMT/UTC)
Falls among older adults represent a growing public health challenge, particularly in low- and middle-income countries like China. While many studies have linked chronic conditions to fall risks, less is known about how patterns of multimorbidity—having multiple chronic diseases—affect the progression or reversal of fall states over time. This study, led by researchers from Peking University and the Chinese PLA General Hospital, examined data from over 14,000 middle-aged and older Chinese adults to explore how different combinations of chronic illnesses influence fall trajectories. Using a longitudinal dataset from the China Health and Retirement Longitudinal Study (CHARLS), the research identified four major multimorbidity patterns and analyzed their impact on transitions between fall states and death.
The findings reveal that individuals with the “osteo-cardiovascular” multimorbidity pattern—those with both cardiovascular and musculoskeletal diseases—face the greatest risk of worsening fall states and mortality, and the least likelihood of recovery. Compared to healthy participants, these individuals were over twice as likely to die and significantly less likely to recover from severe falls. This research highlights the need for clinicians and policymakers to focus fall prevention efforts on patients with high-risk multimorbidity profiles. The study’s insights offer a scientific basis for more targeted health interventions and better allocation of healthcare resources for aging populations.
Opioid use disorder is associated with more than 350,000 deaths annually worldwide. Guided by the need for an increased understanding of critical neurobiological features of addiction, researchers have now found a unique molecular signature and genes in the orbitofrontal cortex associated with heroin-seeking behavior. A preclinical rodent model implicated a gene called Shisa7 as the key predictor. A new study in Biological Psychiatry, published by Elsevier, provides valuable insights into the neurobiological mechanisms underlying heroin addiction and may have implications for the development of innovative strategies to combat the ongoing opioid epidemic.
Los Angeles has some of the strictest tree planting rules in the nation. These policies limit tree growth, worsen shade disparities and don’t improve safety, researchers found. When USC Dornsife researchers modeled looser planting restrictions in a lower-income neighborhood, potential tree space increased by nearly 26%. But narrow sidewalks and dense infrastructure still limited where larger, shade trees could thrive. Many of L.A.’s strict tree-spacing rules are internal guidelines — not laws — meaning they could be updated more easily to allow for more trees. Closing L.A.’s shade gap, however, will require more than policy tweaks; infrastructure investments are also needed.