AI Identifies Key Social Deficits in an Autism Mouse Model Without Prior Knowledge

Developed by Biology-Trained Researchers, Published in Leading Computer Vision Journal IJCV

This Brain Medicine mini-review gathers a decade of converging research on plasma neurofilament light chain (NfL), a protein shed from injured neurons that has become a leading blood-based window onto neuronal damage in Alzheimer’s disease. Synthesizing existing studies rather than reporting new experiments, the authors trace how rising NfL tracks cognitive decline, brain atrophy, and disease progression. Their central argument concerns biological sex. The analysis concludes that an identical NfL level may reflect a more advanced process in men than in women, making sex-specific interpretation a clinical necessity rather than a refinement.

Stress does its damage quietly, and somatostatin may be one of the quietest places it lands. This peer-reviewed Thought Leaders Invited Review gathers fifty years of molecular, circuit, and clinical work to ask how a single inhibitory peptide, and the neurons that carry it, govern the way the brain meets a threat. A consistent shape emerges from the synthesis. Stress reshapes somatostatin signaling across the amygdala, prefrontal cortex, zona incerta, and hippocampus, and the same disruption surfaces in depression, anxiety, and several neurodegenerative diseases. The authors argue these circuits could yield gentler antidepressants, while naming honestly what