In a significant step towards improving targeted cancer therapy, researchers from Japan have developed a novel nanocarrier system that delivers therapeutic antibodies directly to target antigens inside cancer cells. By utilizing a metal-polyphenol network, the system escapes endosomes, enabling intracellular targeting of antibodies, resulting in suppression of tumor growth and enhanced anti-cancer activity, offering a promising tool for targeted cancer therapy.

To simulate blood flow inside brain aneurysms, researchers from Japan developed a computational method that combines 4D flow MRI, computational fluid dynamics, and data assimilation, which provides greater accuracy and efficiency. By focusing only on the aneurysm region, this approach significantly reduces computational cost while improving flow estimation. When validated on patient data, it outperforms conventional models—offering a practical tool for patient-specific risk assessment and treatment strategies.

Inflammation is a natural immune response, but when uncontrolled, it can worsen many diseases. Recent studies show that metabolism plays a surprising role in regulating this response. A new editorial in the Journal of Intensive Medicine highlights findings on the glyoxalase system, a metabolic pathway that helps immune cells tone down inflammation. This insight opens new possibilities for treating inflammatory diseases through metabolic targets, offering a promising direction beyond traditional immunosuppressants.

A new study conducted at Reichman University’s School of Sustainability presents an innovative tool to help decision-makers better understand the condition of streams and thereby advance their restoration and rehabilitation. The tool, called SESBI — the Stream Ecosystem Services and Biodiversity Index — is designed to measure what is called “stream health,” meaning the degree to which a stream functions ecologically and contributes to public welfare.